Product Name: Clozapine N-oxide (CNO)
Subtitle: Metabolite of clozapine, used in chemogenetics.
Biological Activity: Biological Activity of Clozapine N-oxide (CNO)Metabolite of clozapine. Activates human muscarinic designer receptors (DREADDs). Silences hippocampal neurons expressing hM4 DREADDs in vitro. Suppresses food intake in hyperphagic mice with hM3Dq-expressing,
SMLES: C[N+]1(CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl)[O-]
CAS NO: 364782-34-3
Standard In CHIKey: YWSTWDVPYHSYLN-UHFFFAOYSA-NToxins_for_Antibody-drug_conjugates_research_Library inhibitors
Standard InChI: InChI=1S/C18H19ClN4O/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)23(18)24/h2-7,12,24H,8-11H2,1H3
Typrof Compound:
Appearance:
Formula: C18H19ClN4O
M.Wt: 342.82
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/257/1/205
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 20 mM in DMSO and to 20 mM in water
Storage: Store at RT
Purity: >98%
Chemical Name: 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine