Product Name: INCB024360 analogue
Subtitle: potent and selective inhibitor of IDO1
Biological Activity: Biological Activity of INCB024360 analoguePotent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 values are 19 and 67 nM in enzymatic activity and HeLa cell assays, respectively). Decreases kynurenine levels in plasma and reduces tumor growth in vivo. C
SMLES: C1=CC(=C(C=C1NC(=C2C(=NON2)N)N=O)Cl)F
CAS NO: 301836-41-9
Standard In CHIKey: GPR55 inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C9H7ClFN5O2
M.Wt: 271.64
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/255/3/1053
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage: Store at -20℃
Purity: >98%
Chemical Name: 4-Amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide