Product Name: BX 471
Subtitle: CCR1 antagonist,potent and selective
Biological Activity: Biological Activity of BX 471Potent, selective non-peptide CCR1 antagonist (Ki = 1 nM for human CCR1). Exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. Inhibits MIP-α/CCL3-induced intracellular Ca2+ mobilization. Orally active; effec
SMLES: ClC1=CC=C(C(NC(N)=O)=C1)OCC(N2[C@H](C)CN(CC(C=C3)=CC=C3F)CC2)=O
CAS NO: 64849-39-4
Standard In CHIKey: Bacterial inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C21H24ClFN4O3
M.Wt: 434.89
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/264/1/282
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO and to 50 mM in ethanol
Storage: Store at +4℃
Purity: >98%
Chemical Name: (2R)-1-[[2-[(Aminocarbonyl)amino]-4-chlorophenoxy]acetyl]-4-[(4-fluorophenyl)methyl]-2-methylpiperazine