Product Name: CHIR-124
Subtitle: Chk1 inhibitor,novel and potent
Biological Activity: Biological Activity of CHIR-124Description CHIR-124 is a novel and potent inhibitor of Chk1 with an IC50 value of 0.3 nM. Targets Chk1 FLT3 PDGFR GSK-3 Fyn IC50 0.3 nM 5.8 nM 6.6 nM 23.3 nM 98.8 nM
SMLES: C1CN2CCC1C(C2)NC3=C4C=C(C=CC4=NC(=O)C3=C5NC6=CC=CC=C6N5)Cl
CAS NO: 606143-52-6
Standard In CHIKey: MAGL inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C23H22ClN5O
M.Wt: 419.91
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/252/1/327
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: 4-[[(3S)-1-azabicyclo[2.2.2]octan-3-yl]amino]-6-chloro-3-(1,3-dihydrobenzimidazol-2-ylidene)quinolin-2-one