Product Name: Crenolanib (CP-868596)
Subtitle: PDGFR-β inhibitor,potent and selective
Biological Activity: Biological Activity of Crenolanib (CP-868596)Description Crenolanib (CP-868596) is a potent and selective inhibitor of PDGFRα/β with Kd of 2.1 nM/3.2 nM. Targets PDGFRα PDGFRβ IC50 2.1 nM (Kd) 3.2 nM (Kd)
SMLES: CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4
CAS NO: 172922-91-7
Standard In CHIKey: Guanylate Cyclase inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C26H29N5O2
M.Wt: 443.54
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/274/3/1414
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: 1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine