Product Name: Danoprevir (RG7227)
Subtitle: HCV NS3/4A protease inhibitor
Biological Activity: Biological Activity of Danoprevir (RG7227)Description Danoprevir is a highly selective and potent inhibitor of HCV NS3/4A protease with IC50 value of 0.2-3.5 nM. Targets HCV NS3/4A protease IC50 0.2-3.5 nM
SMLES: FC1=CC=CC2=C1CN(C2)C(O[C@@H]3C[C@](C(N[C@@]4(C(NS(=O)(C5CC5)=O)=O)[C@@](/C=CCCCCC[C@@H]6N([H])C(OC(C)(C)C)=O)([H])C4)=O)([H])N(C6=O)C3)=O
CAS NO: 1373423-53-0
Standard In CHIKey: Drug-Linker Conjugates for ADC inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C35H46FN5O9S
M.Wt: 731.83
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/258/1/42
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: (2R,6S,13aS,14aR,16aS,Z)-6-((tert-butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate