Product Name: EPZ5676
Subtitle: DOT1L inhibitor,potent and SAM competitive
Biological Activity: Biological Activity of EPZ5676Description EPZ5676 is a potent and selective inhibitor of DOT1L methyltransferase with Ki value of 80 pM. Targets DOT1L IC50 80 pM (Ki)
SMLES: CC(C)N(CC1C(C(C(O1)N2C=NC3=C2N=CN=C3N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C
CAS NO: 856925-71-8
Standard In CHIKey: Pim inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C30H42N8O3
M.Wt: 562.71
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/253/3/1153
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: (2R,3S,4S,5R)-2-(6-aminopurin-9-yl)-5-[[[3-[2-(6-tert-butyl-1H-benzimidazol-2-yl)ethyl]cyclobutyl]-propan-2-ylamino]methyl]oxolane-3,4-diol