Product Name: Ivacaftor (VX-770)
Subtitle: Potent CFTR potentiator
Biological Activity: Biological Activity of Ivacaftor (VX-770)Description Ivacaftor (VX-770) is a potentiator of CFTR for G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM, respectively. Targets G551D-CFTR F508del-CFTR IC50 100 nM 25 nM
SMLES: CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C
CAS NO: 229975-97-7
Standard In CHIKey: GPR55 inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C24H28N2O3
M.Wt: 392.49
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/258/3/837
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: N-(2,4-ditert-butyl-5-hydroxyphenyl)-4-oxo-1H-quinoline-3-carboxamide