Product Name: K 858
Subtitle:
Biological Activity: Biological Activity of K 858Selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM). Induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells. Displays no effect on microtubule dynamics. Preferentially
SMLES: O=C(C)N1N=C(NC(C)=O)S[C@]1(C)C2=CC=CC=C2
CAS NO: 178616-26-7
Standard In CHIKey: RIP kinase inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C13H15N3O2S
M.Wt: 277.34
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/274/2/695
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO and to 10 mM in ethanol
Storage: Store at +4℃
Purity: >98%
Chemical Name: N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide