Product Name: MK-2461
Subtitle: C-Met (WT/mutants) inhibitor
Biological Activity: Biological Activity of MK-2461Description MK-2461 is a potent, multi-targeted inhibitor of c-Met(WT/mutants) with IC50 values of 0.4-2.5 nM. Targets c-Met (M1250T) c-Met (Y1235D) c-Met (Y1230H) c-Met (N1100) c-Met (Y1230C c-Met IC50 0.4
SMLES: CN1C=C(C=N1)C2=CN=C3C=CC4=C(C=C(C=C4)NS(=O)(=O)N(C)CC5COCCO5)C(=O)C3=C2
CAS NO: 36341-25-0
Standard In CHIKey: RGS Protein inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C24H25N5O5S
M.Wt: 495.55
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/274/3/1552
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: 9-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine