Product Name: MRK 016
Subtitle:
Biological Activity: Biological Activity of MRK 016GABAA receptor inverse agonist selective for the α5-subtype (EC50 = 3 nM). Exhibits affinity at benzodiazepine binding site of recombinant human GABAA receptors (Ki values are 0.77 nM, 0.83 nM, 0.85 nM and 1.4 nM for &#
SMLES: CC(C)(C)C1=C2N(C(C3=NOC(C)=C3)=NN=C2)N=C1OCC4=NC=NN4C
CAS NO:
Standard In CHIKey: Eukaryotic Initiation Factor eIF) inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C17H20N8O2
M.Wt: 368.39
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/272/2/815
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO and to 10 mM in ethanol
Storage: Store at +4℃
Purity: >98%
Chemical Name: 3-(1,1-Dimethylethyl)-7-(5-methyl-3-isoxazolyl)-2-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-pyrazolo[1,5-d][1,2,4]triazine