Product Name: OSI-027
Subtitle: MTORC1/ mTORC2 inhibitor
Biological Activity: Biological Activity of OSI-027Description OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM Targets mTORC mTORC1 mTORC2 PI3Kγ DNA-PK IC50 4 nM 22 nM 65 nM 0.42 μM 1.0 μM
SMLES: COC1=CC=CC2=CC(=C3C4=C(N=CNN4C(=N3)C5CCC(CC5)C(=O)O)N)N=C21
CAS NO: 26027-38-3
Standard In CHIKey: Melatonin Receptor inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C21H22N6O3
M.Wt: 406.45
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/271/1/171
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: 4-[(5Z)-4-amino-5-(7-methoxyindol-2-ylidene)-1H-imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexane-1-carboxylic acid