Product Name: PHA-848125
Subtitle: CDK inhibitor,potent and ATP-competitive
Biological Activity: Biological Activity of PHA-848125Description Milciclib (PHA-848125) is a potent, ATP-competitive inhibitor of CDK with an IC50 value of 45 nM for CDK2. Targets CDK2/CyclinA TrkA CDK7/CyclinH CDK4/CyclinD1 CDK5/p35 IC50 45 nM 53 nM 150
SMLES: CC1(CC2=CN=C(N=C2C3=C1C(=NN3C)C(=O)NC)NC4=CC=C(C=C4)N5CCN(CC5)C)C
CAS NO: 843663-66-1
Standard In CHIKey: NEDD8-activating Enzyme inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C25H32N8O
M.Wt: 460.57
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/252/1/349
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: N,1,4,4-tetramethyl-8-[4-(4-methylpiperazin-1-yl)anilino]-5H-pyrazolo[4,3-h]quinazoline-3-carboxamide