Product Name: PP 2 (AG 1879)
Subtitle: Src-family kinases inhibitor
Biological Activity: Biological Activity of PP 2 (AG 1879)Selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73
SMLES: CC(C)(C)N1C2=C(C(=N1)C3=CC=C(C=C3)Cl)C(=NC=N2)N
CAS NO: 79955-27-4
Standard In CHIKey: PBBRWFOVCUAONR-UHFFFAOYSA-NGNRH Receptor inhibitors
Standard InChI: InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
Typrof Compound:
Appearance:
Formula: C15H16ClN5
M.Wt: 301.78
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/274/3/1348
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 25 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming
Storage: Desiccate at +4℃
Purity: >98%
Chemical Name: 3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine