Product Name: Purvalanol B
Subtitle: CDK1/CDK2/CDK4 inhibitor
Biological Activity: Biological Activity of Purvalanol BCyclin-dependent kinase inhibitor. IC50 values are 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Selective over a range of other protein kinases
SMLES: CC(C)C(CO)NC1=NC2=C(C(=N1)NC3=CC(=C(C=C3)C(=O)O)Cl)N=CN2C(C)C
CAS NO: 1420477-60-6
Standard In CHIKey: PAI-1 inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C20H25ClN6O3
M.Wt: 432.9
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/252/1/358
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in 1eq. NaOH with gentle warming and to 100 mM in DMSO
Storage: Store at +4℃
Purity: >98%
Chemical Name: (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol