Product Name: R547
Subtitle: CDK1/2/4 inhibitor,ATP-competitive
Biological Activity: Biological Activity of R547Description R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki values of 2 nM/3 nM/1 nM, respectively. Targets CDK4/CyclinD1 CDK1/CyclinB CDK2/CyclinE PKA PKB IC50 1 nM(Ki) 2 nM(Ki) 3 nM(Ki) >5
SMLES: COC1=C(C(=C(C=C1)F)F)C(=O)C2=CN=C(N=C2N)NC3CCN(CC3)S(=O)(=O)C
CAS NO: 377727-87-2
Standard In CHIKey: Procollagen C Proteinase inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C18H21F2N5O4S
M.Wt: 441.45
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/252/1/387
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: [4-amino-2-[(1-methylsulfonylpiperidin-4-yl)amino]pyrimidin-5-yl]-(2,3-difluoro-6-methoxyphenyl)methanone