Product Name: Ro3280
Subtitle: PLK1 inhibitor,potent and highly selective
Biological Activity: Biological Activity of Ro3280Description RO3280 is a potent, highly selective inhibitor of Polo-like kinase 1 (PLK1) with an IC50 value of 3 nM. Targets PLK1 IC50 3 nM
SMLES: CN1CCC(CC1)NC(=O)C2=CC(=C(C=C2)NC3=NC=C4C(=N3)N(CC(C(=O)N4C)(F)F)C5CCCC5)OC
CAS NO: 934660-93-2
Standard In CHIKey: RAR_RXR inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C27H35F2N7O3
M.Wt: 543.61
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/252/1/410
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-8H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide