Product Name: SANT-1
Subtitle: Shh inhibitor,potent and cell-permeable
Biological Activity: Biological Activity of SANT-1Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).
SMLES: CC1=C(C(=NN1C2=CC=CC=C2)C)C=NN3CCN(CC3)CC4=CC=CC=C4
CAS NO: 675576-98-4
Standard In CHIKey: CaMK inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C23H27N5
M.Wt: 373.5
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/259/2/932
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 25 mM in ethanol and to 50 mM in DMSO
Storage: Desiccate at +4℃
Purity: >98%
Chemical Name: N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine