Product Name: TAE226 (NVP-TAE226)
Subtitle: FAK inhibitor,potent and ATP-competitive
Biological Activity: Biological Activity of TAE226 (NVP-TAE226)Description TAE226 (NVP-TAE226) is a potent inhibitor of FAK with an IC50 value of 5.5 nM. Targets PYK2 FAK Insulin Receptor IGF-1R c-Met IC50 3.5 nM 5.5 nM 43.5 nM 140 nM 160 nM
SMLES: CNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCOCC4)OC
CAS NO: 262352-17-0
Standard In CHIKey: Immunology_Inflammation inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C23H25ClN6O3
M.Wt: 468.94
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/275/1/114
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: 2-[[5-chloro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]-N-methylbenzamide