Product Name: TAK-285
Subtitle: HER2/EGFR(HER1) inhibitor
Biological Activity: Biological Activity of TAK-285Description TAK-285 is a novel dual inhibitor of HER2 and EGFR(HER1) with IC50 values of 17 nM and 23 nM, respectively. Targets HER2 EGFR/HER1 HER4 MEK1 Aurora B IC50 17 nM 23 nM 260 nM 1.1 μM 1.7 μM
SMLES: CC(C)(CC(=O)NCCN1C=CC2=C1C(=NC=N2)NC3=CC(=C(C=C3)OC4=CC=CC(=C4)C(F)(F)F)Cl)O
CAS NO: 1579991-61-9
Standard In CHIKey: Somatostatin Receptor inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C26H25ClF3N5O3
M.Wt: 547.96
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/274/3/1566
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: N-[2-[4-[3-chloro-4-[3-(trifluoromethyl)phenoxy]anilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethyl]-3-hydroxy-3-methylbutanamide