Product Name: Tipifarnib (Zarnestra)
Subtitle: Farnesyltransferase inhibitor,potent and specific
Biological Activity: Biological Activity of Tipifarnib (Zarnestra)Description Tipifarnib (R115777) is a potent and specific inhibitor of farnesyltransferase (FTase) with IC50 of 0.6 nM. Targets FTase IC50 0.6 nM
SMLES: CN1C=NC=C1C(C2=CC=C(C=C2)Cl)(C3=CC4=C(C=C3)N(C(=O)C=C4C5=CC(=CC=C5)Cl)C)N
CAS NO: 1005342-46-0
Standard In CHIKey: PLHJCIYEEKOWNM-HHHXNRCGSA-NGPR40 inhibitors
Standard InChI: InChI=1S/C27H22Cl2N4O/c1-32-16-31-15-25(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(34)33(24)2)17-4-3-5-21(29)12-17/h3-16H,30H2,1-2H3/t27-/m1/s1
Typrof Compound:
Appearance:
Formula: C27H22Cl2N4O
M.Wt: 489.4
General Tips: for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.PubMed ID:http://jpet.aspetjournals.org/content/258/3/830
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: 6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one