Product Name: Tivantinib (ARQ 197)
Subtitle: C-Met inhibitor,non-ATP-competitive
Biological Activity: Biological Activity of Tivantinib (ARQ 197)Description Tivantinib (ARQ 197) is the first non-ATP-competitive inhibitor of c-Met with Ki of 0.355 μM, little activity to Ron, and no inhibition to EGFR, InsR, PDGFRα or FGFR1/4. Targets c-Met
SMLES: O=C([C@H](C(C1=CC=C2)=CN3C1=C2CCC3)[C@@H]4C5=CNC6=CC=CC=C56)NC4=O
CAS NO: 900185-02-6
Standard In CHIKey: LPL Receptor inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C23H19N3O2
M.Wt: 369.42
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/274/3/1443
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: (3S,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione