Product Name :
Human Hyaluronidase 2/HYAL2 Protein 2524
express system :
HEK293
Product tag :
C-His
Purity:
> 95% as determined by Tris-Bis PAGE
Background:
Hyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive quantities of injected filler. Upregulation of hyaluronidase 2 (HYAL2), one of somatic hyaluronidase (HAase), was demonstrated in granulation tissue during the healing of equine superficial digital flexor tendon injuries.
Molecular Weight:
The protein has a predicted MW of 49.22 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.
Available Size :
100 µg, 500 µg
Endotoxin:
Less than 1EU per μg by the LAL method.
Form :
Lyophilized
Storage Instructions :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer:
Shipped at ambient temperature.
Additional Information:
accession Q12891|express systemHEK293|product tagC-His|purity> 95% as determined by Tris-Bis PAGE|backgroundHyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive quantities of injected filler. Upregulation of hyaluronidase 2 (HYAL2), one of somatic hyaluronidase (HAase), was demonstrated in granulation tissue during the healing of equine superficial digital flexor tendon injuries.|molecular weightThe protein has a predicted MW of 49.22 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.|available size100 g, 500 g|endotoxinLess than 1EU per g by the LAL method.|Human Hyaluronidase 2/HYAL2Protein 2524proteinSize and concentration100, 500g and lyophilizedFormLyophilizedStorage InstructionsValid for 12 months from date of receipt when stored at -80C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.Storage bufferShipped at ambient temperature.Purity> 95% as determined by Tris-Bis PAGEtarget relevanceHyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive quantities of injected filler. Upregulation of hyaluronidase 2 (HYAL2), one of somatic hyaluronidase (HAase), was demonstrated in granulation tissue during the healing of equine superficial digital flexor tendon injuries.Protein namesHyaluronidase-2 (Hyal-2) (EC 3.2.1.35) (Hyaluronoglucosaminidase-2) (Lung carcinoma protein 2) (LuCa-2)Gene namesHYAL2,HYAL2 LUCA2Protein familyGlycosyl hydrolase 56 familyMass9606DaFunctionHydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.Subellular locationCell membrane ; Lipid-anchor, GPI-anchor .TissuesWidely expressed. No expression detected in adult brain.StructureInteracts with MST1R.Target Relevance information above includes information from UniProt accession: Q12891The UniProt Consortium|
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83-46-5 Molecular Weight 70989-04-7 IUPAC Name PMID:26247091 MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com