The NLRP3 inflammasome plays a pivotal role in innate immunity by initiating inflammatory responses upon detection of diverse danger signals. Despite extensive research, the precise mechanism underlying its activation has…
**Background** Fatty acid synthesis is a critical metabolic process that supports the rapid proliferation and survival of various malignant tumors. Acetyl-CoA carboxylase-α (ACCA) serves as a key rate-limiting enzyme in…
Thymic stromal lymphopoietin (TSLP) is a key epithelial-derived cytokine that plays a central role in initiating and amplifying type 2 inflammatory responses, particularly in allergic skin diseases such as atopic…
Tumor-initiating cells (TICs) are pivotal in hepatocellular carcinoma (HCC) progression, recurrence, and metastasis. This study investigates the impact of disulfiram (DSF), an aldehyde dehydrogenase inhibitor, on TICs derived from HCC.…
Herpes simplex virus type 2 (HSV-2) and human immunodeficiency virus type 1 (HIV-1) exhibit a well-documented synergistic relationship, with each infection exacerbating the clinical course of the other. Epidemiological data…