Experimental animal protocols, anesthesia, surgical procedure and publish-surgical analgesia have been approved by the Committee for Animal Experimentation and the Veterinary Authorities of the and cloned by limiting dilution

Osteolytic cancer cell derived noggin might antagonize endogenous, osteoblast-derived BMP-7 and, as a result, allow escape from its inhibitory influence on tumor expansion. Alternatively, osteoblasts might affect tumor progress indirectly,…