Product Name: CGP60474
Subtitle: CDKs and PKC inhibitor, potent
Biological Activity: Biological Activity of CGP60474Potent dual cdk1/cdk2 inhibitor (IC50 values are 20 and 50 nM, respectively). Also displays low micromolar activity at PKCα. Displays reversible G1/S cell cycle arrest in U2-OS cells.
SMLES: c1cc(cc(c1)Cl)Nc2nccc(n2)c3ccnc(c3)NCCCO
CAS NO: 1415716-58-3
Standard In CHIKey: IYNDTACKOAXKBJ-UHFFFAOYSA-NTRP Channel inhibitors
Standard InChI: InChI=1S/C18H18ClN5O/c19-14-3-1-4-15(12-14)23-18-22-9-6-16(24-18)13-5-8-21-17(11-13)20-7-2-10-25/h1,3-6,8-9,11-12,25H,2,7,10H2,(H,20,21)(H,22,23,24)
Typrof Compound:
Appearance:
Formula: C18H18ClN5O
M.Wt: 355.82
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/251/3/949
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
Storage: Store at -20℃
Purity: >98%
Chemical Name: 3-[[4-[2-[(3-Chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol