Product Name: FR 139317
Subtitle:
Biological Activity: Biological Activity of FR 139317A highly potent and selective ETA endothelin receptor antagonist (Ki values are 1 nM and 7.3 μM at ETA and ETB subtypes respectively). Active in vivo.
SMLES: O=C(N[C@H](C(N[C@@H](C(N[C@@H](C(O)=O)CC1=NC=CC=C1)=O)CC2=CN(C)C3=CC=CC=C23)=O)CC(C)C)N4CCCCCC4
CAS NO: 1884712-47-3
Standard In CHIKey: LIOKMIQQPDDTNO-UPRLRBBYSA-NMMP inhibitors
Standard InChI: InChI=1S/C33H44N6O5/c1-22(2)18-26(37-33(44)39-16-10-4-5-11-17-39)30(40)35-27(19-23-21-38(3)29-14-7-6-13-25(23)29)31(41)36-28(32(42)43)20-24-12-8-9-15-34-24/h6-9,12-15,21-22,26-28H,4-5,10-11,16-20H2,1-3H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43)/t26-,27+,28+/m
Typrof Compound:
Appearance:
Formula: C33H44N6O5
M.Wt: 604.75
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/263/2/608
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Storage: Desiccate at +4℃
Purity: >98%
Chemical Name: N-[N-[N-[(Hexahydro-1H-azepin-1-yl)carbonyl]-L-leucyl]-1-methyl-D-tryptophyl]-3-(2-pyridinyl)-D-alanine