Product Name: GSK J4 HCl
Subtitle: Inhibitor of H3K27 demethylase JMJD3,potent and cell-permeable
Biological Activity: Biological Activity of GSK J4 HClHistone lysine demethylase (KDM) inhibitor; blocks demethylation of histone H3K27. Attenuates lipopolysaccharide (LPS)-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhi
SMLES: CCOC(=O)CCNC1=NC(=NC(=C1)N2CCC3=CC=CC=C3CC2)C4=CC=CC=N4.Cl
CAS NO: 1408064-71-0
Standard In CHIKey: Membrane Transporter_Ion Channel inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C24H27N5O2.HCl
M.Wt: 453.96
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/253/3/1236
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage: Store at RT
Purity: >98%
Chemical Name: N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester