Product Name: LY2835219
Subtitle: CDK4/6 inhibitor,potent and selective
Biological Activity: Biological Activity of LY2835219Description LY2835219 is a potent and selective inhibitor of CDK4 and CDK6 with IC50 value of 2 nM and 10 nM, respectively. Targets CDK4 CDK6 IC50 2 nM 10 nM
SMLES: CCN1CCN(CC1)Cc2ccc(nc2)Nc3ncc(c(n3)c4cc5c(c(c4)F)nc(n5C(C)C)C)F.CS(=O)(=O)O
CAS NO: 1218942-37-0
Standard In CHIKey: GlyT inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: ted in 1 % hydroxyethyl cellulose + 0.1 % antifoam in 25 mM PB pH 2 and administered orally by gavage (final volume 0.2 mL). Application LY2835219 mediates CDK4/6 inhibition, cell-cycle arrest and tumor growth inhibition (TGI) in colo-205 an
M.Wt: 602.7
General Tips: for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/251/3/833
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: Abemaciclib mesylate