Product Name: Losmapimod
Subtitle: p38 MAPK inhibitor, orally active
Biological Activity: Biological Activity of LosmapimodDescription Losmapimod (GW856553X) is a selective, potent, and orally active inhibitor of p38 MAPK with a pKi values of 8.1 and 7.6 for p38α and p38β, respectively. Targets p38α p38β IC50 (pKi=8.1) (
SMLES: CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)CO)Cl
CAS NO: 161715-24-8
Standard In CHIKey: Nucleoside Antimetabolite_Analog inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C22H26FN3O2
M.Wt: 383.46
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/255/2/572
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol