Product Name: PF-05212384 (PKI-587)
Subtitle: PI3Kα, PI3Kγ and mTOR inhibitor
Biological Activity: Biological Activity of PF-05212384 (PKI-587)Potent and selective dual inhibitor of PI 3-kinase/mTOR (IC50 values are 0.4, 1.6 and 5.4 nM for PI 3-Kα, mTOR and PI 3-Kγ respectively). Exhibits selectivity over 234 other protein kinases (IC50 >
SMLES: CN(C)C1CCN(CC1)C(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6
CAS NO: 290315-45-6
Standard In CHIKey: MyD88 inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C32H41N9O4
M.Wt: 615.73
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/262/3/964
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 5 mM in DMSO with gentle warming
Storage: Store at -20℃
Purity: >98%
Chemical Name: N-[4-[[4-(Dimethylamino)-1-piperidinyl]carbonyl]phenyl]-N'-[4-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)phenyl]urea