Product Name: XAV-939
Subtitle: Tankyrase 1/2 inhibitor
Biological Activity: Biological Activity of XAV-939Potent tankyrase (TNKS) inhibitor (IC50 values are 4 and 11 nM for TNKS2 and TNKS1 respectively). Antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of th
SMLES: C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
CAS NO: 1446502-11-9
Standard In CHIKey: PTEN inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C14H11F3N2OS
M.Wt: 312.31
General Tips: for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.PubMed ID:http://jpet.aspetjournals.org/content/252/2/574
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 20 mM in DMSO
Storage: Store at RT
Purity: >98%
Chemical Name: 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one