Product Name: ABT-751 (E7010)Subtitle: Inhibitor of microtubule polymerization,antimitoticBiological Activity: Biological Activity of ABT-751 (E7010)Antimitotic agent, inhibits microtubule polymerization. Binds to β-tubulin on the colchine site; blocks cell cycle at G2M…
Product Name: Rigosertib (ON-01910,Estybon)Subtitle: Plk1 inhibitorBiological Activity: Biological Activity of Rigosertib (ON-01910,Estybon)Description Rigosertib is a non-ATP-competitive small-molecule inhibitor of Plk1 with IC50 value of 9 nM. Targets Plk1 IC50 9…
Product Name: Zoledronic AcidSubtitle: Potent nitrogen-containing bisphosphonatesBiological Activity: SMLES: c1cn(cn1)CC(O)(P(=O)(O)O)P(=O)(O)OCAS NO: 530141-72-1Standard In CHIKey: XRASPMIURGNCCH-UHFFFAOYSA-NCFTR inhibitorsStandard InChI: InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)Typrof Compound: Appearance: Formula: C5H10N2O7P2M.Wt: 272.09General Tips: For obtaining a higher solubility ,…
Product Name: 10058-F4Subtitle: C-Myc-Max dimerization inhibitorBiological Activity: Biological Activity of 10058-F4Cell permeable c-Myc-Max dimerization inhibitor. Inhibits proliferation, induces apoptosis and arrests cells in G0/G1 in rat1a-c-Myc cells. Also reduces tumor…
Product Name: Vincristine sulfateSubtitle: Microtubule disrupter,antitumor agentBiological Activity: Biological Activity of Vincristine sulfate Anticancer agent; microtubule disrupter. Induces apoptosis in human lymphoma cells.SMLES: CC1(O)C2CN(CCc3c(c4ccccc34)(C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)7(O)((OC(C)=O)8(CC)C=CCN9CC6789)C(=O)OC)C1.O(O)(=O)=OCAS NO: 1181770-72-8Standard In CHIKey: AQTQHPDCURKLKT-JKDPCDLQSA-NBCRP inhibitorsStandard…
Product Name: PodophyllotoxinSubtitle: AntineoplasticBiological Activity: Biological Activity of Podophyllotoxin 1. Podophyllotoxin has antineoplastic and antiviral properties. 2. Podophyllotoxin is an antimitotic agent,had been used for the treatment of genital warts.SMLES:…
Product Name: PaclitaxelSubtitle: Antineoplastic agentBiological Activity: Biological Activity of Paclitaxel Antitumor agent; promotes and stabilizes tubulin polymerization, causing cell cycle arrest. Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering…
Product Name: DocetaxelSubtitle: Microtubulin disassembly inhibitorBiological Activity: Biological Activity of Docetaxel Binds and stabilizes microtubules; leads to cell cycle arrest and apoptosis. Displays significant antitumor activity in ovarian and gastric…
Product Name: ColchicineSubtitle: Tubulin InhibitorBiological Activity: Biological Activity of Colchicine Plant-derived alkaloid that binds to tubulin and depolymerizes microtubules.SMLES: COC1=CC=C2C(=CC1=O)(CCc3cc(OC)c(OC)c(OC)c23)NC(C)=OCAS NO: 1474110-21-8Standard In CHIKey: IAKHMKGGTNLKSZ-INIZCTEOSA-NRaf inhibitorsStandard InChI: InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1Typrof Compound: AlkaloidsAppearance:…
Product Name: 7-XylosyltaxolSubtitle: Taxol (Paclitaxel) derivativeBiological Activity: Biological Activity of 7-Xylosyltaxol 1. 7-xylosyltaxol is a taxol (Paclitaxel) derivative, has antineoplastic activity.SMLES: CAS NO: 915363-56-3Standard In CHIKey: p38 MAPK inhibitorsStandard InChI:…