Product Name: HLI 373Subtitle: Hdm2 ubiquitin ligase (E3) inhibitorBiological Activity: Biological Activity of HLI 373Inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent…
Product Name: Cyclic Pifithrin-α hydrobromideSubtitle: P53 inhibitorBiological Activity: Biological Activity of Cyclic Pifithrin-α hydrobromideCyclic analog of pifithrin-α, a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes…
Product Name: CP 31398 dihydrochlorideSubtitle: p53 stabilizerBiological Activity: Biological Activity of CP 31398 dihydrochloridep53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines…
Product Name: TLQP 21Subtitle: VGF-derived peptideBiological Activity: Biological Activity of TLQP 21VGF-derived peptide; spans residues 556-576 of the precursor sequence. Protects cerebellar granule cells (CGCs) from serum and potassium deprivation-induced…
Product Name: NQDI 1Subtitle: ASK1, MAP3K5 inhibitorBiological Activity: Biological Activity of NQDI 1Selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50 = 3 μM, Ki = 500 nM).SMLES: O=C1NC2=CC=CC3=C2C(C4=CC=CC=C4C3=O)=C1C(OCC)=OCAS…
Product Name: MelphalanSubtitle: DNA alkylating agentBiological Activity: Biological Activity of MelphalanDNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA. Inhibits growth of PC-3…
Product Name: Mdivi 1Subtitle: Selective DRP1/Dnm1 inhibitor, cell-permeableBiological Activity: Biological Activity of Mdivi 1Selective inhibitor of Dnm1 GTPase (IC50 = 1 – 10 μM); attenuates Dnm1- and Drp1-mediated mitochondrial division.…
Product Name: GRI 977143Subtitle: LPA2 receptor non-lipid agonistBiological Activity: Biological Activity of GRI 977143Selective lysophosphatidic acid 2 (LPA2) receptor non-lipid agonist (EC50 = 3.3 μM). Does not activate other LPA…
Product Name: DAPK Substrate PeptideSubtitle: Synthetic peptide substrate for DAPKBiological Activity: Biological Activity of DAPK Substrate PeptideSynthetic peptide substrate for death associated protein kinase (DAPK) (Km = 9 μM).SMLES: CC1=CC(=C(C(=C1)C)NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)CCAS…
Product Name: Cesium chlorideSubtitle: Potassium channel blockerBiological Activity: Biological Activity of Cesium chloridePotassium channel blocker; inhibits the pacemaker current (If) and the hyperpolarization-activated cationic current (Ih). Prevents activation of caspase-3…