C 75
Product Name: C 75Subtitle: Fatty acid synthase (FAS) inhibitorBiological Activity: Biological Activity of C 75Synthetic inhibitor of fatty acid synthase (FASN); inhibits fatty acid synthesis in vitro and in vivo.…
Actinomycin D
Product Name: Actinomycin DSubtitle: RNA polymerase inhibitorBiological Activity: Biological Activity of Actinomycin DAnti-neoplastic antibiotic. Inhibits RNA polymerase and is a potent inducer of apoptosis.SMLES: CAS NO: 201410-53-9Standard In CHIKey: RJURFGZVJUQBHK-UHFFFAOYSA-NWee1…
2,3-DCPE hydrochloride
Product Name: 2,3-DCPE hydrochlorideSubtitle: Bcl-XL protein expression downregulatorBiological Activity: SMLES: ClC1=CC=CC(OCCCNCCO)=C1Cl.ClCAS NO: 1243244-14-5Standard In CHIKey: QVEIRCZEBQRCTR-UHFFFAOYSA-OTopoisomerase inhibitorsStandard InChI: InChI=1S/C11H15Cl2NO2/c12-9-3-1-4-10(11(9)13)16-8-2-5-14-6-7-15/h1,3-4,14-15H,2,5-8H2/p+1Typrof Compound: Appearance: Formula: C11H15Cl2NO2.HClM.Wt: 300.61General Tips: For obtaining a higher solubility…
R18
Product Name: R18Subtitle: 14.3.3 proteins AntagonistBiological Activity: Biological Activity of R18Antagonist of 14.3.3 proteins (KD ≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to…
PETCM
Product Name: PETCMSubtitle: Caspase-3 activatorBiological Activity: Biological Activity of PETCMCaspase-3 activator. Acts via inhibition of the oncoprotein ProT, therefore stimulates apoptosome formation and subsequent caspase-3 activation in a cytochrome c-dependent…
Ac-LEHD-AFC
Product Name: Ac-LEHD-AFCSubtitle: Fluorogenic caspase substrateBiological Activity: Biological Activity of Ac-LEHD-AFCFluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.SMLES: CAS NO: 1402836-58-1Standard In CHIKey: Sirtuin inhibitorsStandard InChI: Typrof Compound: Appearance:…
Ivachtin
Product Name: IvachtinSubtitle: Caspase-3 inhibitorBiological Activity: SMLES: CC1=C2C(=C3C=C(C=CC3=N1)S(=O)(=O)N4CCOCC4)C(=O)N(C2=O)CCOC(=O)CCAS NO: 1186206-79-0Standard In CHIKey: ROCK inhibitorsStandard InChI: Typrof Compound: Appearance: Formula: C20H21N3O7SM.Wt: 447.46General Tips: For obtaining a higher solubility , please warm…
AZ 10417808
Product Name: AZ 10417808Subtitle: Caspase-3 inhibitor,selective non-peptideBiological Activity: Biological Activity of AZ 10417808Selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6,…
TW-37
Product Name: TW-37Subtitle: Bcl-2 inhibitor, inhibits Bcl-2,Bcl-XL and Mcl-1Biological Activity: Biological Activity of TW-37Bcl-2 inhibitor (Ki values are 0.29 μM and 1.11 μM for Bcl-2 and Bcl-XL respectively). Inhibits the…
NSC 66811
Product Name: NSC 66811Subtitle: MDM2 inhibitorBiological Activity: Biological Activity of NSC 66811Potent MDM2 inhibitor (Ki = 120 nM) which disrupts MDM2-p53 interaction and activates p53 function. Induces p21, p53 and…