Product Name: Nutlin-3Subtitle: MDM2 antagonist,inhibits MDM2-p53 interactionBiological Activity: Biological Activity of Nutlin-3Description Nutlin-3 is a potent and selective antagonist of Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53)…
Product Name: GDC-0152Subtitle: IAP antagonist,potent amd samll-moleculeBiological Activity: Biological Activity of GDC-0152Description GDC-0152 is a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins with Ki values of 28, 14,…
Product Name: YM155Subtitle: Survivin suppressant,apoptosis inhibitorBiological Activity: Biological Activity of YM155Description YM155 (Sepantronium Bromide) is a potent inhibitor of Survivin promoter activity with IC50 of 0.54 nM. Targets Survivin IC50…
Product Name: Birinapant (TL32711)Subtitle: Potent XIAP/cIAP1 antagonistBiological Activity: Biological Activity of Birinapant (TL32711)Description Birinapant is an antagonist of XIAP and cIAP1 with Kd value of 45 nM and
Product Name: Necrostatin-1Subtitle: RIP1 inhibitorBiological Activity: Biological Activity of Necrostatin-1ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a…
Product Name: Pomalidomide (CC-4047)Subtitle: Immunomodulator,antumor/anti-angiogenicBiological Activity: Biological Activity of Pomalidomide (CC-4047)Description Pomalidomide is an inhibitor of LPS-induced TNF-α release with IC50 of 13 nM. Targets TNF-α IC50 13 nMSMLES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCAS…
Product Name: Lenalidomide (CC-5013)Subtitle: Antineoplastic agent,inhibits angiogenesisBiological Activity: Biological Activity of Lenalidomide (CC-5013)Description Lenalidomide (CC-5013) is an inhibitor of TNF-α secretion with IC50 of 13 nM. Targets TNF-α IC50 13…
Product Name: NSC 207895 (XI-006)Subtitle: MDMX inhibitor,anti-cancer agentBiological Activity: Biological Activity of NSC 207895 (XI-006)Description NSC 207895 is an anticancer agent. Targets E3 ligase MDM2 MDMX IC50SMLES: CN1CCN(CC1)C2=CC=C(C3=NO(=C23))(=O)CAS NO: 905579-51-3Standard…
Product Name: NSC 319726Subtitle: Reactivator of mutant p53Biological Activity: Biological Activity of NSC 319726Reactivator of mutant p53. Restores wild type p53 structure and function to the p53R175 mutant. Inhibits growth…
Product Name: Pifithrin-α (PFTα)Subtitle: p53 inhibitorBiological Activity: Biological Activity of Pifithrin-α (PFTα)Inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and…