Product Name: AZD-5438
Subtitle: Potent CDK1/2/9 inhibitor
Biological Activity: Biological Activity of AZD-5438Potent inhibitor of cyclin-dependent kinase (cdk) 1, 2 and 9 (IC50 values are 16, 6 and 20 nM respectively). Exhibits antiproliferative activity in human tumor cell lines. Blocks cell cycling at G2-M, S and G1 phases; reduce
SMLES:
CAS NO: 232931-57-6
Standard In CHIKey: HMG-CoA Reductase HMGCR) inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C18H21N5O2S
M.Wt: 371.46
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/252/1/293
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO
Storage: Desiccate at RT
Purity: >98%
Chemical Name: 4-[2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine