Product Name: Clofarabine
Subtitle: Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase
Biological Activity: Biological Activity of ClofarabineDeoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Indu
SMLES: c1nc2c(nc(nc2n1[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)F)Cl)N
CAS NO: 950769-58-1
Standard In CHIKey: WDDPHFBMKLOVOX-AYQXTPAHSA-NPI3K inhibitors
Standard InChI: InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3(1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
Typrof Compound:
Appearance:
Formula: C10H11ClFN5O3
M.Wt: 303.68
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/252/2/552
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 10 mM in water and to 100 mM in DMSO
Storage: Desiccate at +4℃
Purity: >98%
Chemical Name: 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine