Product Name: Cladribine
Subtitle: Apoptosis inducer in CLL cells
Biological Activity: Biological Activity of CladribineAdenosine deaminase (ADA)-resistant analog of deoxyadenosine. Exhibits anti-leukemic activity; Inhibits cell growth of lymphoid and myeloid neoplasm (IC50 = 20 – 87 nM). Pro-apoptotic; induces DNA double-strand breaks. Als
SMLES: C1C(C(OC1N2C=NC3=C2N=C(N=C3N)Cl)CO)O
CAS NO: 208255-80-5
Standard In CHIKey: PTOAARAWEBMLNO-KVQBGUIXSA-NBMX Kinase inhibitors
Standard InChI: InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
Typrof Compound:
Appearance:
Formula: C10H12ClN5O3
M.Wt: 285.69
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/252/2/605
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO
Storage: Store at +4℃
Purity: >98%
Chemical Name: (2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxalan-3-ol