Product Name: JNJ-26481585
Subtitle: Potent HDAC inhibitor
Biological Activity: Biological Activity of JNJ-26481585Description Quisinostat (JNJ-26481585) is a novel second-generation inhibitor of HDAC with highest potency for HDAC1 with IC50 of 0.11 nM. Targets HDAC1 HDAC2 HDAC4 HDAC10 HDAC11 IC50 0.11 nM 0.33 nM
SMLES: CN1C=C(C2=CC=CC=C21)CNCC3CCN(CC3)C4=NC=C(C=N4)C(=O)NO
CAS NO: 648450-29-7
Standard In CHIKey: beta)-catenin inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: ted at 2 mg/mL in 20% hydroxypropyl-β-cyclodextrin (final pH 8.7). Application In the HDAC1-responsive A2780 ovarian tumor screening model, JNJ-26481585 induces a bright and intense fluorescence, which is not uniformly distributed throughout
M.Wt: 394.48
General Tips: for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/252/2/840
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: N-hydroxy-2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]pyrimidine-5-carboxamide