Product Name: VX-680 (MK-0457,Tozasertib)
Subtitle: Aurora kinase inhibitor
Biological Activity: Biological Activity of VX-680 (MK-0457,Tozasertib)High affinity and selective Aurora kinase inhibitor (Ki values are 0.6, 5 and 18 nM for Aurora A, Aurora C and Aurora B, respectively). Also exhibits affinity for FLT-3 and Abl. Exhibits selectivity for Au
SMLES: CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
CAS NO: 1354825-58-3
Standard In CHIKey: LPL Receptor inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C23H28N8OS
M.Wt: 464.59
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/253/2/784
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO
Storage: Store at -20℃
Purity: >98%
Chemical Name: