Product Name: CYT387
Subtitle: JAK-1/-2 inhibitor,ATP competitive
Biological Activity: Biological Activity of CYT387Description Momelotinib (CYT387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Targets JAK1 JAK2 JAK3 IC50 11 nM 18 nM 155 nM
SMLES: C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N
CAS NO: 1404456-53-6
Standard In CHIKey: IFNAR inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C23H22N6O2
M.Wt: 414.46
General Tips: for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/253/3/1063
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: N-(cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide