Product Name: Olaparib (AZD2281, Ku-0059436)
Subtitle: Potent PARP1/PARP2 inhibitor
Biological Activity: Biological Activity of Olaparib (AZD2281, Ku-0059436)Olaparib (AZD2281, KU0059436) is a potent inhibitor of PARP1 and PARP2 with IC50 of 5 and 1 nM, respectively. Targets PARP1 PARP2 IC50 5 nM 1 nM
SMLES: C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
CAS NO: 223488-57-1
Standard In CHIKey: PGE synthase inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C24H23FN4O3
M.Wt: 434.46
General Tips: for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.PubMed ID:http://jpet.aspetjournals.org/content/253/3/1097
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: 4-[[3-[4-(cyclopropanecarbonyl)piperazine-1-carbonyl]-4-fluorophenyl]methyl]-2H-phthalazin-1-one