Product Name: SGI-1776 free base
Subtitle: Pim kinase inhibitor,ATP-competitive
Biological Activity: Biological Activity of SGI-1776 free baseDescription SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM, 50- and 10-fold selective versus Pim2 and Pim3. Targets Pim1 Pim2 Pim3 FLT3 IC50 7 nM 363 nM 69 nM 44nM
SMLES: CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2
CAS NO: 147127-20-6
Standard In CHIKey: BCRP inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C20H22F3N5O
M.Wt: 405.42
General Tips: for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.PubMed ID:http://jpet.aspetjournals.org/content/253/3/1253
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine