Product Name :
SBI-0640756
Description:
SBI-0640756 (SBI-756) is an inhibitor of eIF4G1 and disrupts the eIF4F complex.
CAS:
1821280-29-8
Molecular Weight:
404.82
Formula:
C23H14ClFN2O2
Chemical Name:
6-chloro-3-[(2E)-3-(5-fluoropyridin-3-yl)prop-2-enoyl]-4-phenyl-1,2-dihydroquinolin-2-one
Smiles :
O=C1NC2C=CC(Cl)=CC=2C(=C1C(=O)/C=C/C1C=NC=C(F)C=1)C1C=CC=CC=1
InChiKey:
VVWGPQZBDQVQRC-RMKNXTFCSA-N
InChi :
InChI=1S/C23H14ClFN2O2/c24-16-7-8-19-18(11-16)21(15-4-2-1-3-5-15)22(23(29)27-19)20(28)9-6-14-10-17(25)13-26-12-14/h1-13H,(H,27,29)/b9-6+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Stavudine Technical Information
Shelf Life:
≥12 months if stored properly.Recombinant Murine Interleukin-6MedChemExpress
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:34142612
Additional information:
SBI-0640756 (SBI-756) is an inhibitor of eIF4G1 and disrupts the eIF4F complex.|Product information|CAS Number: 1821280-29-8|Molecular Weight: 404.82|Formula: C23H14ClFN2O2|Chemical Name: 6-chloro-3-[(2E)-3-(5-fluoropyridin-3-yl)prop-2-enoyl]-4-phenyl-1,2-dihydroquinolin-2-one|Smiles: O=C1NC2C=CC(Cl)=CC=2C(=C1C(=O)/C=C/C1C=NC=C(F)C=1)C1C=CC=CC=1|InChiKey: VVWGPQZBDQVQRC-RMKNXTFCSA-N|InChi: InChI=1S/C23H14ClFN2O2/c24-16-7-8-19-18(11-16)21(15-4-2-1-3-5-15)22(23(29)27-19)20(28)9-6-14-10-17(25)13-26-12-14/h1-13H,(H,27,29)/b9-6+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 26 mg/mL (64.23 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SBI-0640756 (SBI-756) is a water soluble inhibitor of eIF4G1. SBI-0640756 (SBI-756) (0-1 μM) disrupts eIF4F complex in parent and BRAFi-resistant melanoma. SBI-0640756 (SBI-756) shows inhibitory effect on human melanoma lines, and also suppresses AKT, NF-κB and AKT/mTORC1 activity.|In Vivo:|SBI-0640756 (SBI-756) (0.5 mg/kg, i.p.) delays tumor onset and reduces tumor incidence by 50% in NrasQ61K/Ink4a–/– genetic model. SBI-0640756 (SBI-756) (1 mg/kg, 2 times per week, i.p.) in combination with BRAF inhibitor potently suppresses growth of established tumors and does not resume tumor growth in immunodeficient mice bearing A375 tumors.|Products are for research use only. Not for human use.|