VX-745
Product Name: VX-745Subtitle: P38α inhibitor,highly potent and selectiveBiological Activity: Biological Activity of VX-745Highly potent and selective p38α inhibitor (IC50 = 10 nM). Also blocks TNFα production in LPS-stimulated HWB in…
ZM336372
Product Name: ZM336372Subtitle: C-Raf inhibitor, potent and selectiveBiological Activity: Biological Activity of ZM336372Potent, selective inhibitor of c-Raf in vitro (IC50 = 70 nM for inhibition of human c-Raf). Shows 10-fold…
AZD8330
Product Name: AZD8330Subtitle: MEK 1/2 inhibitorBiological Activity: Biological Activity of AZD8330Description AZD8330 is a novel, selective, non-ATP competitive inhibitor of MEK 1/2 with an IC50 value of 7 nM. Targets…
AZ 628
Product Name: AZ 628Subtitle: Raf kinases,potent and ATP-competitiveBiological Activity: Biological Activity of AZ 628Potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E…
PH-797804
Product Name: PH-797804Subtitle: P38 MAP kinase inhibitor, potent and selectiveBiological Activity: Biological Activity of PH-797804Description PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM; 4-fold more…
FR 180204
Product Name: FR 180204Subtitle: ERK inhibitorBiological Activity: Biological Activity of FR 180204Selective ERK inhibitor (IC50 values are 0.14 and 0.31 μM for ERK2 and ERK1 respectively). Displays 30-fold selectivity for…
SB 203580
Product Name: SB 203580Subtitle: P38 MAP kinase inhibitorBiological Activity: Biological Activity of SB 203580Selective inhibitor of p38 MAPK (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively).…
TAK-632
Product Name: TAK-632Subtitle: Pan-RAF inhibitor,potent and selectiveBiological Activity: Biological Activity of TAK-632Description TAK-632 is a potent inhibitor of Raf with IC50 of 8.3 nM and 1.4 nM for B-Raf(wt) and…
AZD6244 (Selumetinib)
Product Name: AZD6244 (Selumetinib)Subtitle: MEK inhibitorBiological Activity: Biological Activity of AZD6244 (Selumetinib)Description Selumetinib (AZD6244) is a potent, highly selective inhibitor of MEK1 with IC50 of 14 nM. Targets MEK1 IC50…
BIX 02188
Product Name: BIX 02188Subtitle: MEK5 inhibitor,potent and selectiveBiological Activity: Biological Activity of BIX 02188Description BIX02188 is a selective inhibitor of MEK5 with an IC50 value of 4.3 nM. Targets MEK5…