TC-A 2317 hydrochloride
Product Name: TC-A 2317 hydrochlorideSubtitle: Aurora kinase A inhibitor,potent and selectiveBiological Activity: Biological Activity of TC-A 2317 hydrochloridePotent Aurora kinase A inhibitor (Ki = 1.2 nM compared to 101 nM…
SGI-1776 free base
Product Name: SGI-1776 free baseSubtitle: Pim kinase inhibitor,ATP-competitiveBiological Activity: Biological Activity of SGI-1776 free baseDescription SGI-1776 is a novel ATP competitive inhibitor of Pim1 with IC50 of 7 nM, 50-…
GSK J1
Product Name: GSK J1Subtitle: H3K27 demethylase JMJD3 inhibitorBiological Activity: Biological Activity of GSK J1Potent inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) (IC50 values are 28 and…
GSK J4 HCl
Product Name: GSK J4 HClSubtitle: Inhibitor of H3K27 demethylase JMJD3,potent and cell-permeableBiological Activity: Biological Activity of GSK J4 HClHistone lysine demethylase (KDM) inhibitor; blocks demethylation of histone H3K27. Attenuates lipopolysaccharide…
Bromosporine
Product Name: BromosporineSubtitle: Bromodomain inhibitor,non-selectiveBiological Activity: Biological Activity of BromosporineDescription Bromosporine is a non-selective inhibitor of bromodomain. Targets bromodomain IC50SMLES: CC1=C(NS(C)(=O)=O)C=C(C2=NN3C(C(NC(OCC)=O)=C2)=NN=C3C)C=C1CAS NO: 219989-84-1Standard In CHIKey: Ribosomal S6 Kinase RSK) inhibitorsStandard…
PFI-1 (PF-6405761)
Product Name: PFI-1 (PF-6405761)Subtitle: BET inhibitorBiological Activity: Biological Activity of PFI-1 (PF-6405761)Potent BET bromodomain inhibitor; exhibits inhibitory activity at bromodomain-containing protein (BRD) 2 and BRD4 (IC50 values are 98 and…
Sirtinol
Product Name: SirtinolSubtitle: SIRT inhibitorBiological Activity: Biological Activity of SirtinolCell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 μM at SIRT2, Sir2p and SIRT1 respectively) that has…
EX 527 (SEN0014196)
Product Name: EX 527 (SEN0014196)Subtitle: SIRT1 inhibitorBiological Activity: Biological Activity of EX 527 (SEN0014196)Selective inhibitor of SIRT1 that does not inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members…
SRT1720 HCl
Product Name: SRT1720 HClSubtitle: SIRT1 activatorBiological Activity: Biological Activity of SRT1720 HClDescription SRT1720 is a selective activator of SIRT1 with EC50 of 0.16 μM, but is >230-fold less potent for…
SGI-110
Product Name: SGI-110Subtitle: DNA methyltransferases inhibitor,potentBiological Activity: Biological Activity of SGI-110Description SGI-110 is a dinucleotide antimetabolite of decitabine linked via phosphodiester bond to a guanosine Targets DNA Methyltransferase IC50SMLES: C1C(C(OC1N2C=NC3=C2NC(=NC3=O)N)COP(=O)(O)OC4CC(OC4CO)N5C=NC(=NC5=O)N)OCAS…