Product Name: SGI-110Subtitle: DNA methyltransferases inhibitor,potentBiological Activity: Biological Activity of SGI-110Description SGI-110 is a dinucleotide antimetabolite of decitabine linked via phosphodiester bond to a guanosine Targets DNA Methyltransferase IC50SMLES: C1C(C(OC1N2C=NC3=C2NC(=NC3=O)N)COP(=O)(O)OC4CC(OC4CO)N5C=NC(=NC5=O)N)OCAS…
Product Name: EPZ005687Subtitle: EZH2 inhibitor,potent and selectiveBiological Activity: Biological Activity of EPZ005687Description EPZ005687 is a potent and selective inhibitor of EZH2 with Ki of 24 nM, 50-fold selectivity against EZH1…
Product Name: EPZ004777Subtitle: DOT1L inhibitorBiological Activity: Biological Activity of EPZ004777Highly potent DOT1L inhibitor (IC50 = 0.4 nM). Exhibits >1000-fold selectivity for DOT1L over a panel of other methyltransferases. Selectively inhibits…
Product Name: EntacaponeSubtitle: COMT inhibitorBiological Activity: Biological Activity of EntacaponePotent catechol O-methyltransferase (COMT) inhibitor (IC50 values are 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and…
Product Name: SGC 0946Subtitle: DOT1L inhibitor,highly potent and selectiveBiological Activity: Biological Activity of SGC 0946Description SGC 0946 is a potent inhibitor of DOT1L methyltransferase with IC50 value of 0.3 nM.…
Product Name: EPZ5676Subtitle: DOT1L inhibitor,potent and SAM competitiveBiological Activity: Biological Activity of EPZ5676Description EPZ5676 is a potent and selective inhibitor of DOT1L methyltransferase with Ki value of 80 pM. Targets…
Product Name: AZD2461Subtitle: Novel PARP inhibitorBiological Activity: Biological Activity of AZD2461Description AZD2461 is a novel inhibitor of PARP. Targets PARP IC50SMLES: CAS NO: 174484-41-4Standard In CHIKey: EGFR inhibitorsStandard InChI: Typrof…
Product Name: UPF 1069Subtitle: Selective PARP2 inhibitorBiological Activity: Biological Activity of UPF 1069Selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).SMLES:…
Product Name: INO-1001Subtitle: Potent PARP inhibitorBiological Activity: Biological Activity of INO-1001An inhibitor of poly(ADP-ribose) polymerase, which protects cells from UV-B-induced apoptosis via influence on the cytoskeleton.SMLES: C1=CC(=CC(=C1)N)C(=O)NCAS NO: 148717-90-2Standard In…
Product Name: A-966492Subtitle: PARP-1/-2 inhibitor, highly potentBiological Activity: Biological Activity of A-966492A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM,…