Product Name: PJ34 hydrochlorideSubtitle: PARP inhibitor,potent and cell-permeableBiological Activity: Biological Activity of PJ34 hydrochloridePotent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM). ~1000-fold more potent than 3-Aminobenzamide. Protects primary…
Product Name: Iniparib (BSI-201)Subtitle: PARP1 inhibitor,intravenously adminsiteredBiological Activity: Biological Activity of Iniparib (BSI-201)PARP1 inhibitor. Inhibits growth of certain breast cancer cell lines in vitro. Non-selectively modifies cysteine-containing proteins in tumor…
Product Name: Rucaparib (AG-014699,PF-01367338)Subtitle: Potent PARP inhibitorBiological Activity: Biological Activity of Rucaparib (AG-014699,PF-01367338)Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP1 with Ki of 1.4 nM. Targets PARP IC50 1.4 nM…
Product Name: Olaparib (AZD2281, Ku-0059436)Subtitle: Potent PARP1/PARP2 inhibitorBiological Activity: Biological Activity of Olaparib (AZD2281, Ku-0059436)Olaparib (AZD2281, KU0059436) is a potent inhibitor of PARP1 and PARP2 with IC50 of 5 and…
Product Name: S-Ruxolitinib (INCB018424)Subtitle: JAK1/2 inhibitor,potent and selectiveBiological Activity: Biological Activity of S-Ruxolitinib (INCB018424)Description S-Ruxolitinib is the chirality of INCB018424. Targets JAK1 JAK2 JAK3 IC50 3.3 nM 2.8 nM 428…
Product Name: LY2784544Subtitle: JAK2 inhibitor,highly potent and selectiveBiological Activity: Biological Activity of LY2784544Description LY2784544 is a highly potent and selective inhibitor of wild-type JAK2 and V617F mutant JAK2 with IC50…
Product Name: CEP-33779Subtitle: JAK2 inhibitor,highly selectiveBiological Activity: Biological Activity of CEP-33779Description CEP-33779 is a selective inhibitor of JAK2 with IC50 value of 1.8 nM. Targets JAK2 IC50 1.8 nMSMLES: CN1CCN(CC1)C2=CC(=CC=C2)NC3=NN4C=CC=C(C4=N3)C5=CC=C(C=C5)S(=O)(=O)CCAS…
Product Name: AZ 960Subtitle: JAKs inhibitorBiological Activity: Biological Activity of AZ 960Description AZ 960 is a potent, selective and ATP competitive inhibitor of JAK2 with Ki value of 0.45 nM.…
Product Name: CYT387Subtitle: JAK-1/-2 inhibitor,ATP competitiveBiological Activity: Biological Activity of CYT387Description Momelotinib (CYT387) is an ATP-competitive inhibitor of JAK1/JAK2 with IC50 of 11 nM/18 nM, ~10-fold selectivity versus JAK3. Targets…
Product Name: Baricitinib (LY3009104, INCB028050)Subtitle: JAK1/JAK2 inhibitor,selective orally bioavailableBiological Activity: Biological Activity of Baricitinib (LY3009104, INCB028050)Description Baricitinib (LY3009104, INCB028050) is a selective inhibitor of JAK1 and JAK2 with IC50 values…