Product Name: RG 108Subtitle: DNA methyltransferase inhibitorBiological Activity: Biological Activity of RG 108Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines…
Product Name: LomeguatribSubtitle: MGMT inhibitorBiological Activity: Biological Activity of LomeguatribInhibitor of O6-methylguanine-DNA methyltransferase (MGMT); (IC50 = 0.009 μM in cell-free extracts from HeLa S3 cells); attenuates MGMT activity in vitro…
Product Name: Bromodomain Inhibitor, (+)-JQ1Subtitle: BET bromodomain inhibitorBiological Activity: Biological Activity of Bromodomain Inhibitor, (+)-JQ1Potent, high affinity, selective BET bromodomain inhibitor (IC50 values are 17.7, 32.6, 76.9 and 12942 nM…
Product Name: BIX 01294Subtitle: G9a and GLP inhibitorBiological Activity: Biological Activity of BIX 01294Description BIX 01294 is an inhibitor of G9a-like protein and G9a histone lysine methyltransferase with IC50 value…
Product Name: 5-AzacytidineSubtitle: DNA methyltransferase inhibitor.Biological Activity: Biological Activity of 5-AzacytidineDNA methyltransferase inhibitor. Incorporates into DNA forming covalent adducts with cellular DNMT1, depleting enzyme activity. Induces demethylation and reactivation of…
Product Name: 3-Deazaneplanocin,DZNepSubtitle: Cell-permeable histone methyltransferase inhibitorBiological Activity: Biological Activity of 3-Deazaneplanocin,DZNepDescription 3-deazaneplanocin A (DZNeP), an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50…
Product Name: ResveratrolSubtitle: Biological Activity: Biological Activity of Resveratrol A phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. Inhibits cytochrome P450 1A1 (IC50 = 23 μM) and displays mixed…
Product Name: Ginkgolic acid C15:0Subtitle: HAT inhibitorBiological Activity: Biological Activity of Ginkgolic acid C15:0 Noncompetitive inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50 values are ~5.0 and ~8.5…
Product Name: 5-Aza-2-deoxycytidineSubtitle: Deoxycytidine analog and cellular diifferentiation inducerBiological Activity: Biological Activity of 5-Aza-2-deoxycytidine Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits…
Product Name: Endomorphin-2Subtitle: Biological Activity: Biological Activity of Endomorphin-2Endogenous peptide with extremely high affinity and selectivity for μ-opioid receptors (with Ki values of 0.69, 9233 and 5240 nM for μ,…